FIS ha laboratori e risorse allo stato dell’arte nell’ambito della chimica analitica dedicata allo sviluppo di processo e produzione di principi attivi farmaceutici e loro intermedi.
FIS è praticamente indipendente in ogni test analitico sia esso di natura fisica o prettamente di carattere chimico. Dispone di ambienti controllati per il supporto degli studi di stabilità secondo ICH.
Traditional techniques
- Thin-layer chromatography
- Melting point determination
- Titrations
- Water content determination (Volumetric and coulometrico)
Separation sciences
- HPLC and UPLC (multiple detectors e.g. UV, Fluorescence, CAD, Refractive index, Mass, ELSD, Polarimetric)
- Gas chromatography (multiple detectors)
- Head space Gas chromatography
- Preparative HPLC
- Ion chromatography
- U -SFC, prep-SFC, GC-SFC
Spectroscopy
- Infrared spectroscopy IR
- Ultraviolet-Visible spectroscopy UV-Vis
- Atomic absorption
- ICP Inductively coupled plasma – OES
- ICP Inductively coupled plasma – MS
Spectrometry
- NMR
- Mass Spectroscopy Single/Triple quadrupole, ToF
- NIR
- Powder colorimeter
Solid state characterization techniques
- Electronic Microscope SEM
- Particle size distribution determination (by laser light scattering e.g. Malvern 2000, Malvern 3000, Simpatec, Microtrac3500 or mechanical Alpine, Retsch)
- XRPD X-Ray powder diffraction
- Thermal analysis (DSC and TGA)
Other analytical techniques
- Polarimetry
- Particular matter test
- Water Activity test
- Appearance (including microscope, foreign matter test, colour determination, white index, etc.)
- LAL test and all microbiological tests