{"id":8114,"date":"2026-06-10T09:42:56","date_gmt":"2026-06-10T09:42:56","guid":{"rendered":"https:\/\/fisvi.com\/lpps-peptide-synthesis\/"},"modified":"2026-09-02T09:30:58","modified_gmt":"2026-09-02T09:30:58","slug":"lpps-peptide-synthesis","status":"publish","type":"page","link":"https:\/\/fisvi.com\/it\/lpps-peptide-synthesis\/","title":{"rendered":"LPPS &#8211; Peptide Synthesis"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"8114\" class=\"elementor elementor-8114 elementor-8004\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-433562e e-con-full e-flex e-con e-parent\" data-id=\"433562e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4158641 elementor-widget elementor-widget-text-editor\" data-id=\"4158641\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>As peptide therapies move toward the market, efficient and cost effective large scale production becomes essential. Liquid Phase Peptide Synthesis (LPPS) is increasingly adopted for peptide API manufacturing thanks to its scalability and more sustainable profile, with reduced solvent use. At FIS, we support the transition from clinical development to commercial supply with robust LPPS capabilities, designed for projects where purity, cost control, and scale matter.  <\/p><p>Discover how we do it through the voices of our experts.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b7ebad9 e-flex e-con-boxed e-con e-parent\" data-id=\"b7ebad9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-59a65c2 e-con-full e-flex e-con e-child\" data-id=\"59a65c2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0e90c48 elementor-widget elementor-widget-video\" data-id=\"0e90c48\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;hosted&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t\t\t\t<div class=\"e-hosted-video elementor-wrapper elementor-open-inline\">\n\t\t\t\t\t<video class=\"elementor-video\" src=\"https:\/\/fisvi.com\/wp-content\/uploads\/2026\/06\/lpps-01-why-lpps-2026.mp4\" controls=\"\" preload=\"metadata\" controlsList=\"nodownload\"><\/video>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e5bc1ff elementor-widget elementor-widget-heading\" data-id=\"e5bc1ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Why LPPS<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f45b0fb elementor-widget elementor-widget-text-editor\" data-id=\"f45b0fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Peptide therapies are advancing rapidly. Manufacturing must keep pace.<br \/>As products move toward commercialization, manufacturers face increasing pressure to deliver: <\/p><ul><li>scale<\/li><li>cost efficiency<\/li><li>sostenibilita<\/li><\/ul><p>Traditional approaches often rely heavily on end-stage purification, creating a significant manufacturing bottleneck.<\/p><p>This is one of the reasons why Liquid Phase Peptide Synthesis is gaining attention as a scalable and efficient route to peptide API manufacturing.<\/p><p>In this video, our colleagues <strong>Roberto Profeta<\/strong> and <strong>Deepshikha Angrish<\/strong> share why it matters.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-eb9a32f e-con-full e-flex e-con e-child\" data-id=\"eb9a32f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-187bcc2 elementor-widget elementor-widget-video\" data-id=\"187bcc2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;hosted&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t\t\t\t<div class=\"e-hosted-video elementor-wrapper elementor-open-inline\">\n\t\t\t\t\t<video class=\"elementor-video\" src=\"https:\/\/fisvi.com\/wp-content\/uploads\/2026\/06\/lpps-02-lpps-at-fis-2026.mp4\" controls=\"\" preload=\"metadata\" controlsList=\"nodownload\"><\/video>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6da3b97 elementor-widget elementor-widget-heading\" data-id=\"6da3b97\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">LPPS at FIS<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-085bb1e elementor-widget elementor-widget-text-editor\" data-id=\"085bb1e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>How does FIS approach LPPS?<\/p><p>At FIS, LPPS starts with process chemistry. Our convergent strategies are designed to generate key peptide fragments with high purity, helping simplify downstream processing and support industrial scale-up. From clinical supply to commercial manufacturing, <strong>FIS<\/strong> combines:  <\/p><ul><li>process chemistry expertise<\/li><li>large-scale manufacturing capabilities<\/li><li>a strong focus on purity and cost control.<\/li><\/ul><p>Hear from <strong style=\"font-family: -apple-system, BlinkMacSystemFont, &apos;Segoe UI&apos;, Roboto, &apos;Helvetica Neue&apos;, Arial, &apos;Noto Sans&apos;, sans-serif, &apos;Apple Color Emoji&apos;, &apos;Segoe UI Emoji&apos;, &apos;Segoe UI Symbol&apos;, &apos;Noto Color Emoji&apos;\">Roberto Profeta<\/strong> and <strong style=\"font-family: -apple-system, BlinkMacSystemFont, &apos;Segoe UI&apos;, Roboto, &apos;Helvetica Neue&apos;, Arial, &apos;Noto Sans&apos;, sans-serif, &apos;Apple Color Emoji&apos;, &apos;Segoe UI Emoji&apos;, &apos;Segoe UI Symbol&apos;, &apos;Noto Color Emoji&apos;\">Deepshikha Angrish<\/strong> <span style=\"font-family: -apple-system, BlinkMacSystemFont, &apos;Segoe UI&apos;, Roboto, &apos;Helvetica Neue&apos;, Arial, &apos;Noto Sans&apos;, sans-serif, &apos;Apple Color Emoji&apos;, &apos;Segoe UI Emoji&apos;, &apos;Segoe UI Symbol&apos;, &apos;Noto Color Emoji&apos;\">in this new video.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-891408d e-con-full e-flex e-con e-child\" data-id=\"891408d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-838e0cd elementor-widget elementor-widget-video\" data-id=\"838e0cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;hosted&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t\t\t\t<div class=\"e-hosted-video elementor-wrapper elementor-open-inline\">\n\t\t\t\t\t<video class=\"elementor-video\" src=\"https:\/\/fisvi.com\/wp-content\/uploads\/2026\/07\/lpps-03-why-fistag.mp4\" controls=\"\" preload=\"metadata\" controlsList=\"nodownload\"><\/video>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a68df0 elementor-widget elementor-widget-heading\" data-id=\"7a68df0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Why FISTag<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90f5530 elementor-widget elementor-widget-text-editor\" data-id=\"90f5530\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Innovation in LPPS requires the right enabling technologies. That&#8217;s why FIS developed FISTag\u2122, our proprietary tagging platform designed to strengthen peptide manufacturing processes.<br \/>FISTag\u2122 helps: <\/p><ul><li>support purity through controlled precipitation and crystallization<\/li><li>improve solubility<\/li><li>enable more efficient processing.<\/li><\/ul><p>It also supports a more sustainable manufacturing approach, as the tag can be recovered and recycled at the end of synthesis.<\/p><p>In this video, <strong>Roberto Profeta<\/strong> and <strong>Deepshikha Angrish<\/strong> explain how FISTag\u2122 enhances the FIS approach to peptide manufacturing.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e28d937 e-flex e-con-boxed e-con e-parent\" data-id=\"e28d937\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9d9b68a elementor-widget elementor-widget-global elementor-global-6664 elementor-global-859 elementor-widget-spacer\" data-id=\"9d9b68a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b8543d e-flex e-con-boxed e-con e-parent\" data-id=\"2b8543d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e673877 elementor-widget elementor-widget-heading\" data-id=\"e673877\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">White paper<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4356ae0 elementor-widget elementor-widget-heading\" data-id=\"4356ae0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Beyond Solubility: How Crystallisation-Driven Fragment Purification with FISTag\u2122 Improves Final Peptide Yield and Quality<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f52bdc4 elementor-widget elementor-widget-text-editor\" data-id=\"f52bdc4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The therapeutic peptide market has been transformed in less than a decade. Semaglutide, Tirzepatide, and a deep pipeline of follow-on dual and triple agonists have moved peptides from a specialist niche into one of the highest-volume small-molecule-adjacent manufacturing challenges in the industry. <\/p><p>The question is no longer whether a peptide can be made \u2014 it is whether it can be made reproducibly, at scale, at a cost of goods that supports commercial pricing, and at a quality that satisfies the impurity control expectations set out by regulatory agencies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3adfdbc elementor-widget elementor-widget-heading\" data-id=\"3adfdbc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Where the established routes struggle<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a15d886 elementor-widget elementor-widget-text-editor\" data-id=\"a15d886\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Solid-phase peptide synthesis (SPPS) remains the workhorse of clinical-stage peptide development, but at commercial scale it presents well-documented economic and environmental challenges: high resin and solvent consumption, unacceptable PMIs, and limited productivity.<\/p><p>As chain length increases, the statistical accumulation of deletion and modification impurities means the crude SPPS product entering final purification carries a complex similarity-impurity profile. These critical similarity impurities (CSIs) are not removed by scale \u2014 they are concentrated by it. As batch sizes grow into the multi-kilogram and tonne range required for blockbuster peptides, chromatographic recovery yields fall, solvent consumption climbs disproportionately, and meaningful quantities of qualified API are discarded in side fractions to meet purity specifications.  <\/p><p>Current tag-assisted LPPS platforms have addressed several of these limitations by enabling convergent assembly, but they have been designed around a single optimisation target: maximising solubility. Fragment intermediates isolated by massive precipitation typically reach &lt;90% purity by HPLC area \u2014 leaving the deletion, diastereomeric, and modification variants that become overlapping peaks, challenging to remove later. <\/p><p>This is the central commercial problem. Achieving a final API specification of NMT 0.10\u20130.15% for any single specified impurity requires aggressive heart-cutting, with main-fraction recoveries that can fall below 50% on a mass basis. The lever with the greatest financial impact is not improving the resolution of the final column \u2014 it is removing the CSIs before they get there.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6bc4a27 elementor-widget elementor-widget-heading\" data-id=\"6bc4a27\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">FISTag\u2122: a different question<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-96bc55d elementor-widget elementor-widget-text-editor\" data-id=\"96bc55d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>FIS approached the design question from a different direction. We asked: what tag architecture, attached to a growing protected peptide fragment, would template a reproducible, well-ordered and easily filtrable crystalline solid \u2014 across a range of fragment sequences and lengths? <\/p><p>The FISTag\u2122 tag combines three functional elements: a peptide attachment handle for stable, orthogonal linkage compatible with standard Fmoc and Boc based LPPS couplings; a crystallisation-directing scaffold that biases the tagged fragment toward accessible, thermodynamically stable crystal forms; and a solubility-modulating region tuned so that controlled crystallisation can be triggered reproducibly when needed.<\/p><p>By placing the crystallisation-directing functionality in the tag rather than relying only on the peptide sequence, the solid form behaviour is dominated by tag-tag interactions and is less sequence-dependent. The consequence: accessible, reproducible solid forms within weeks rather than months of solid-state development for new fragments. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9f47fc4 elementor-widget elementor-widget-heading\" data-id=\"9f47fc4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Results<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ad5d44 elementor-widget elementor-widget-text-editor\" data-id=\"6ad5d44\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>A series of 4-6mer GLP relevant fragments were prepared with consistent 99+% purity \u2014 clean compounds eligible as new Regulatory Starting Materials (RSMs) for convergent synthesis of more complex APIs. More advanced 8-12mer intermediates were also prepared at Kilo lab scale, reaching consistently 97%+ purities and good yield, with a consistent control strategy. The advanced clean protected fragments, condensed into the final crude API, reached &gt;90% purity prior to chromatography.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a5cacc6 elementor-widget elementor-widget-heading\" data-id=\"a5cacc6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">The bottom line<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc922e7 elementor-widget elementor-widget-text-editor\" data-id=\"bc922e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>FISTag\u2122 reframes the design objective of tag-assisted LPPS: by engineering the tag for crystallisation rather than solubility alone, FIS has built a fragment synthesis platform that purges critical similarity impurities at the point in the route where they are still simple to remove \u2014 through a unit operation that is mature, scalable, regulator-friendly, and economically efficient.<\/p><p>The downstream consequence is materially improved final peptide yield, lower cost of goods, and a more defensible impurity control strategy. For peptide programmes approaching late-stage clinical or commercial supply \u2014 particularly high-volume GLP-1 and related long-peptide programmes \u2014 FISTag\u2122 offers a route to commercial viability that conventional SPPS and current solubility-focused tag-assisted LPPS approaches struggle to match. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1fbf96b elementor-widget elementor-widget-heading\" data-id=\"1fbf96b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">About FIS<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fbf1ca3 elementor-widget elementor-widget-text-editor\" data-id=\"fbf1ca3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>FIS is a global \u201csmall molecule\u201d CDMO with decades of experience designing and optimising commercial API manufacturing routes. Building the most efficient, cost-effective synthetic pathway to a high-purity active ingredient is our core discipline, one that demands rigorous process chemistry, deep understanding of impurity fate and purge, and a relentless focus on cost of goods. FISTag\u2122 is the product of applying that same discipline to peptide synthesis: a tag-assisted LPPS platform engineered to bring small molecule production efficiencies to the manufacture of complex peptides.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce0dea5 elementor-widget elementor-widget-heading\" data-id=\"ce0dea5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Want to learn more and download the full article?<\/br>Leave your email address:<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-331f72d elementor-widget elementor-widget-shortcode\" data-id=\"331f72d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><script>\nvar 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Liquid Phase Peptide Synthesis (LPPS) is increasingly adopted for peptide API manufacturing thanks to its scalability and more sustainable profile, with reduced solvent use. 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